MondalS
Chemical Biology Lab
We are a chemical biology research group. Our objective is to integrate chemistry and biology to address diverse biomedical problems. Currently we are focused on three major areas:
Drug Development against Therapy-resistant Cancers: Although numerous cancer therapies are developed to date, a key challenge is the emergence of resistance mechanisms that evade the toxicity of anticancer drugs. Cancer cells exploit different pathways, including up- or downregulation of certain proteins/enzymes to resist the cell death mechanisms. To treat therapy-resistant cancers, we are developing novel therapeutic candidates that inhibit or degrade proteins/enzymes associated with the therapy-resistance.
Selective Activation of Cancer Therapeutics: Chemotherapeutics are one of the major therapies used to treat a variety of cancers. However, often times, chemotherapeutics require cancer cell-targeting moieties, such as monoclonal antibodies, integrin-binding ligands and receptor agonists to selectively kill cancer cells. We are pursuing this project to activate chemotherapeutics selectively in the cancer cells.
Drug development against Proteinopathies: Protein aggregation is at the forefront of several amyloid diseases, including Parkinson's disease, Alzheimer's Disease, systemic amyloidoses, Amyotrophic Lateral Sclerosis and many more. We are pursuing this project to develop small molecule drugs that inhibit the aggregation of amyloidogenic proteins by targeting different species in the amyloidosis pathway. We are also interested in developing drugs that remove the toxic amyloid aggregates from the body.
Laboratory: Our chemical biology laboratory is located at the ground floor of KSBS, Block-IA, IIT Delhi.
